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Your Position: > Thrombopoietin R

Thrombopoietin R

요약

Name:Thrombopoietin receptor
Target Synonym:CD110 Antigen,THCYT2,C-MPL,CD110,MPLV,Receptors, Thrombopoietin,MPL,TPOR,Myeloproliferative leukemia protein,Myeloproliferative Leukemia Virus Oncogene,Proto-Oncogene C-Mpl,TPO-R,MPL Proto-Oncogene, Thrombopoietin Receptor,Thrombopoietin Receptor,THPOR
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

제품 리스트 구매

일부의 생물활성 데이터

THR-M52H3-SPR
 Thrombopoietin R SPR

Mouse Thrombopoietin R Protein, His Tag (Cat. No. THR-M52H3) capture on NTA-Series S sensor chip can bind Human Thrombopoietin Protein, Tag Free (Cat. No. THN-H5214) with an affinity constant of 5.67 nM as determined in a SPR assay (Biacore 8K) (QC tested).

THR-H52H7-SPR
 Thrombopoietin R SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, premium grade (Cat. No. THN-H5214) with an affinity constant of 2.32 nM as determined in SPR assay (Biacore T200) (QC tested).

Synonym Name

MPL,C-MPL,CD110,MPLV,THCYT2,TPOR

Background

Thrombopoietin R, also known as TPO-R, is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). Binding of TPO to the megakaryocyte TPO-R leads to different effects: prevention of megakaryocyte apoptosis; increased megakaryocyte number, size, and ploidy; increasing rate of megakaryocyte maturation; and internalization of the TPO/TPO-R complex. Thrombopoietin R involved in multiple signal transduction pathways, such as JAK, STAT, and MAP kinase.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human thrombopoietin biosimilar (Biolotus) Approved Biolotus Zypotin-TPO Brazil Thrombocytopenia Biolotus 2015-01-01 Thrombocytopenia Details
Lusutrombopag S-888711 Approved Shionogi & Co Ltd Mulpleta EU Thrombocytopenia Shionogi Bv 2015-09-28 Thrombocytopenia Details
Romiplostim AMP-2; AMG-531 Approved Amgen Inc Romiplate, Nplate Mainland China Purpura, Thrombocytopenic, Idiopathic Kyowa Hakko Kirin China Pharmaceutical Co Ltd 2008-08-22 Bone Marrow Failure Disorders; Carcinoma, Non-Small-Cell Lung; Lymphoma, Non-Hodgkin; Lymphoma; Lung Neoplasms; Thrombocytopenia; Purpura, Thrombocytopenic; Acute Radiation Syndrome; Pancytopenia; Anemia, Aplastic; Purpura, Thrombocytopenic, Idiopathic; Multiple Myeloma; Hodgkin Disease; Myeloproliferative Disorders; Myelodysplastic Syndromes; Neoplasms; Hematologic Neoplasms; Ovarian Neoplasms; Solid tumours Details
Recombinant human thrombopoietin rhTPO (3SBio) Approved Shenyang Sunshine Pharmaceutical Co Ltd 特比奥, Tpiao, 特比澳 Mainland China Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic null 2005-03-10 Leukemia; Purpura, Thrombocytopenic, Idiopathic; Plasmacytoma; Liver Cirrhosis; Sepsis; Neoplasms; Liver Diseases; Multiple Myeloma; Breast Neoplasms; Thrombocytopenia; Leukemia, Myeloid, Acute; Lymphoma; Myelodysplastic-Myeloproliferative Diseases Details
Eltrombopag Diolamine SB-497115; SB-497115-GR; ETB-115 Approved Glaxosmithkline Plc Promacta, Revolade, Promacta/Revolade, 瑞弗兰, レボレード Mainland China Purpura, Thrombocytopenic, Idiopathic Novartis Pharma Schweiz Ag 2008-11-20 Hepatitis C; Leukemia, Megakaryoblastic, Acute; Blast Crisis; Bone Marrow Failure Disorders; Hemorrhage; Multiple Myeloma; Hepatitis B; Anemia, Aplastic; Sarcoma; Osteosarcoma; Leukemia, Basophilic, Acute; Delayed Graft Function; Leukemia, Myeloid, Chronic-Phase; Primary Myelofibrosis; Thrombocytopenia; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Hepatitis C, Chronic; Leukemia, Eosinophilic, Acute; Catheter-Related Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Purpura; HIV Infections; Hematologic Neoplasms; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid, Accelerated Phase; Bone marrow transplant rejection; Hematopoietic stem cell transplantation (HSCT); Leukemia; Leukemia, Myeloid; Wiskott-Aldrich Syndrome; Non-alcoholic Fatty Liver Disease; Purpura, Thrombocytopenic, Idiopathic; Myelodysplastic Syndromes; Liver Cirrhosis; Neoplasms, Connective and Soft Tissue; Blood Platelet Disorders; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Anemia, Diamond-Blackfan; Fanconi An Details
Herombopag Olamine SHR-8735 Approved Jiangsu Hengrui Medicine Co Ltd 恒曲 Mainland China Anemia, Aplastic; Thrombocytopenia Jiangsu Hengrui Medicine Co Ltd 2021-06-16 Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Anemia, Aplastic; Breast Neoplasms; Thrombocytopenia; Carcinoma, Non-Small-Cell Lung Details
Avatrombopag Maleate YM-477; AKR-501; AS-1670542; AKR-501-monomaleate; E-5501 Approved Astellas Pharma Inc Doptelet, 苏可欣 Mainland China Liver Diseases; Thrombocytopenia Eisai Co Ltd Kawashima Plant 2018-05-21 Purpura, Thrombocytopenic, Idiopathic; Drug-Related Side Effects and Adverse Reactions; Neoplasms; Blood Platelet Disorders; Liver Diseases; Cardiovascular Diseases; Thrombocytopenia; Lymphoma Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Romiplostim biosimilar (Enzene Biosciences) 267639-76-9 Phase 3 Clinical Enzene Biosciences Ltd Purpura, Thrombocytopenic, Idiopathic Details
Romiplostim biosimilar (Intas Pharmaceuticals) Phase 3 Clinical Intas Biopharmaceuticals Purpura, Thrombocytopenic, Idiopathic Details
Recombinant human thrombopoietin mimetics (Shandong Quangang) Phase 1 Clinical Shandong Quangang Pharmaceutical Co Ltd Purpura, Thrombocytopenic, Idiopathic Details
PEGylated thrombopoietin (Chongqing Paijin Bio) Phase 1 Clinical Chongqing Paijin Biotechnology Co Ltd Thrombocytopenia Details
Romiplostim biosimilar(Generium) GNR-069 Phase 3 Clinical Cjsc Generium Purpura, Thrombocytopenic, Idiopathic Details
SCB-219 SCB-219-M; SCB-219; SCB-219M Phase 1 Clinical Sichuan Sanyecao Bio-Pharmaceutical Co Ltd Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia Details
Thrombopoietin agonist (Scripps Research) 3D9 Clinical The Scripps Research Institute Inc Thrombocytopenia Details
Recombinant human thrombopoietin(Peking University People's Hospital) Phase 2 Clinical Peking University People'S Hospital Purpura, Thrombocytopenic, Idiopathic Details

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